Parkinson’s disease

How does aerobic exercise impact motor symptom progression in individuals with Parkinson’s disease?

1134 755 Maggie Ford, MD

Previous studies have shown that physical exercise can improve motor symptoms in Parkinson’s disease (PD).1,2 In a recent single-centre, prospective, Phase 2, double-blind, randomised, placebo-controlled trial called Park-in-Shape, Van der…

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Journal watch: The neuropsychiatry of Parkinson’s disease: advances and challenges

850 567 Maggie Ford, MD

The Background Although Parkinson’s disease (PD) is well known for its motor symptoms its associated neuropsychiatric symptoms should not be overlooked.1 Neuropsychiatric symptoms are common in all stages of PD,…

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Deep brain stimulation in Parkinson’s disease – five-year outcomes

2560 1707 Anna Stelling, PhD

It has been consistently shown that deep brain stimulation (DBS) in combination with medication is superior to medication alone in mid- and advanced-stage Parkinson’s disease (PD).1 These findings also motivated…

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Smartphone-controlled device could revolutionise drug delivery in the brain

3450 2300 Peter Stevenson, PhD

A novel brain implant that can deliver drugs and stimulate brain cells could lead to advanced treatments for Parkinson’s, Alzheimer’s, and other brain disorders, a new study reports. The research comes…

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Serum NfL levels shine a light on neuroaxonal damage and disease

4089 2300 Michael Furrer, PhD

The 5th Annual Congress of the European Academy of Neurology (EAN) in Oslo, Norway, featured an in-depth exploration of the role of neurofilament light chain (NfL) protein levels as a…

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Cellular power failures linked to Parkinsonism

3150 2100 Mea Holm, PhD

Mounting evidence is linking neurodegenerative disorders, such as Parkinsonism and dementia, with mitochondrial dysfunction.1 At the 5th Annual Congress of the European Academy of Neurology (EAN) in Oslo, Norway, the…

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Young neurons in mature brains

3150 2100 Peter Stevenson, PhD

A new study uncovered the existence of immature neurons in adult brains well into old age, adding more weight to the longstanding debate of whether neurogenesis really stops after adolescence.…

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Gene therapy shows promise in Parkinson’s disease

2100 1400 Mea Holm, PhD

Interim results from a Phase Ib trial show that gene therapy may reduce the need for medication in patients with Parkinson’s disease refractory to levodopa. The investigational therapy is designed…

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New molecule could halt neural damage in Parkinson’s disease

2967 1980 Peter Stevenson, PhD

Researchers may have found a way to halt, and even reverse, the neural damage associated with Parkinson’s disease (PD) using a novel molecule that targets a key cause of nerve…

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Breath test could detect early stage Parkinson’s

1920 1080 Peter Stevenson, PhD

A simple breath test for detection of early-stage Parkinson’s disease (PD) could one day be an effective, portable diagnostic tool – even outside the clinic – according to new research.…

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